pISSN 2671-8790 eISSN 2671-8804

View

Article View

Korean J Transplant 2022; 36(2): 99-103

Published online June 30, 2022

https://doi.org/10.4285/kjt.22.0011

© The Korean Society for Transplantation

Laboratory support of ABO antibody monitoring for ABO-incompatible solid organ transplantation

Yousun Chung1 , Dae-Hyun Ko2

1Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea
2Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Correspondence to: Dae-Hyun Ko
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-4504
Fax: +82-2-478-0884
E-mail: daehyuni1118@amc.seoul.kr

Received: March 4, 2022; Revised: April 6, 2022; Accepted: April 17, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The accurate measurement of ABO antibodies is essential for successful ABO-incompatible solid organ transplantation. Titration using two-fold dilution is considered a standard method and is applied in most laboratories. However, this titration method has inherent limitations, including differences in methods between laboratories, a lack of standardization, its semiquantitative nature, and the difficulty of considering the results to be representative of the in vivo activity of ABO antibodies. Various measurement methods other than titration have been developed, and new methods continue to be introduced. Physicians and laboratory specialists who are involved in ABO-incompatible solid organ transplantation need to fully understand these methods for optimal patient management.

Keywords: ABO incompatible, Transplantation, Antibody, Titer, Monitor

HIGHLIGHTS
  • The accurate measurement of ABO antibodies is essential for successful ABO-incompatible solid organ transplantation.

  • Titration has been used for a long time, but has many limitations.

  • Physicians should be aware of the characteristics of ABO antibody testing methods for successful transplantation.