pISSN 2671-8790 eISSN 2671-8804

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Korean J Transplant 2021; 35(2): 108-111

Published online June 30, 2021

https://doi.org/10.4285/kjt.20.0058

© The Korean Society for Transplantation

Severe anorexia and weight loss induced by tacrolimus in kidney transplant recipients

Hong Pil Hwang1,2,3 , Hee Chul Yu1,2,3 , Byeoung Hoon Chung1,2,3 , Kyung Pyo Kang2,3,4 , Won Kim2,3,4 , Sung Kwang Park2,3,4 , Sik Lee2,3,4

1Department of General Surgery, Jeonbuk National University Hospital, Jeonju, Korea
2Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, Korea
3Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea
4Department of Internal Medicine, Jeonbuk National University Hospital, Jeonju, Korea

Correspondence to: Sik Lee
Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea
Tel: +82-63-250-2151
Fax: +82-63-255-1609
E-mail: kidney@jbnu.ac.kr

Received: December 21, 2020; Revised: February 9, 2021; Accepted: February 10, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Common neuropsychiatric complications of tacrolimus include tremors, fatigue, headache, sleep disorders, paranoid reactions, and anxiety. Other, more serious complications include encephalopathy, convulsions, confusion, and coma. To our knowledge, however, severe weight loss by anorexia has not been reported as a neuropsychiatric adverse effect of tacrolimus given to adult kidney transplant recipients. In this article we present two cases of severe anorexia and weight loss associated with tacrolimus that appeared to reverse with cyclosporine.

Keywords: Anorexia, Weight loss, Tacrolimus, Kidney transplantation

HIGHLIGHTS
  • We present two cases of severe anorexia and weight loss associated with tacrolimus that appeared to reverse with cyclosporine.