pISSN 2671-8790 eISSN 2671-8804

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J Korean Soc Transplant 2013; 27(2): 42-48

Published online June 30, 2013

https://doi.org/10.4285/jkstn.2013.27.2.42

© The Korean Society for Transplantation

Pathologic Updates on Antibody Mediated Rejection in Renal Transplantation

Yeong-Jin Choi, M.D., Ph.D.

Department of Hospital Pathology, Seoul St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea

Correspondence to: 최영진, 서울시 서초구 반포동 505 서울성모병원 병리과, 137-701
Tel: 02-2258-1616, Fax: 02-2258-1627
E-mail: mdyjchoi@catholic.ac.kr

Received: June 10, 2013; Revised: June 14, 2013; Accepted: June 14, 2013

Abstract

Progress in the field of antibody mediated rejection (ABMR) in kidney transplantation has shown a rapid increase during the past two decades. New pathologic entities have emerged and replace old concepts and diagnostic terms. According to newly acknowledged facts discovered by clinicians, researchers, and pathologists all over the world, an updated classification, rather than Banff 07, is needed. In order to improve the diagnostic accuracy for ABMR in clinicians as well as pathologists, recognition and awareness of various conditions such as C4d-negative ABMR, subclinical ABMR, de novo donor specific antibody, microcirculation inflammation, isolated vascular lesion, antibody-mediated transplant arteriopathy, etc. are essentially important.

Keywords: Antibodies, Graft rejection, Complement C4d, Transplantation, Kidney