Table. 1.

AT1R antibodies in KT

Study No. of recipients Time of detection Cutoff Key finding
Dragun et al. (2005) [8] 33 With rejection Post-KT NA (bioassay) 16 Patients with malignant hypertension and rejection had AT1R Ab(+)DSA(−) AT1R Ab(+)DSA(−) patients had rapid allograft loss than AT1R Ab(−)DSA(+) patients.
Reinsmoen et al. (2010) [9] 63 With no DSA or MICA-DSA Pre & post-KT 17 Units Six of 7 AMR patients had AT1R Ab(+) at post-KT.
Giral et al. (2013) [10] 599 Pre-KT 10 U Pre-KT AT1R Ab was associated with acute rejection and increased graft failure after 3 years post-KT.
Taniguchi et al. (2013) [11] 351: 134 With rejection, 217 control Pre & post-KT 15 U/mL De novo AT1R Ab was associated with graft failure.
Banasik et al. (2014) [29] 117 Pre & post-KT 9 U/mL Pre-KT AT1R Ab was risk factor for graft failure. Patients with AT1R Ab showed more severe Banff grade.
Fuss et al. (2015) [31] 11 With C4d negative antibody mediated rejection without DSA Pre & post-KT 10 U/mL All patients had pre-KT or post-KT AT1R Ab (+). All patients responded to anti-rejection therapy, which included plasma exchange and angiotensin receptor blocker therapy.
Lee et al. (2015) [30] 53 With rejection Post-KT 10 U/mL AT1R Ab was associated with HLA class-I DSA. Presence of both AT1R Ab(+) and DSA(+) was associated with AMR.
Lee et al. (2015) [36] 75 With AMR Pre & post-KT 15 U/mL Nine patients were pre-KT AT1R Ab(+) and 10 patients were AT1R Ab(+) at the time of biopsy.
Cuevas et al. (2016) [34] 141 Pre-KT 10, 17, 30 U Higher (>30 U) pre-KT AT1R Ab were risk factor for earlier development of de novo DSA.
Deltombe et al. (2017) [35] 940 Pre-KT 10, 17 U/mL Did not confirm of association between pre-KT AT1R Ab with transplant outcome.
Lee et al. (2017) [12] 166 Pre-KT 9.05 U/mL Pre-KT AT1R Ab was risk factor for acute rejection, especially acute cellular rejection.
Lim et al. (2017) [37] 27 With rejection and no DSA Pre-KT 17 U/mL Patients with AT1R Ab(+) had more AMR and microcirculation inflammation.
Philogene et al. (2017) [27] 70 Post-KT 10, 17 U/mL AT1R Ab levels were higher in patients with AMR than no rejection. Microcirculation inflammation was higher in patients with higher (>17) AT1R Ab.
Pinelli et al. (2017) [38] 142 Pre & post-KT 17 U/mL No statistical association was found.
Fichtner et al. (2018) [28] 62 (Pediatric) Post-KT 9.5 U/mL AT1R Ab was associated with AMR and adverse graft outcome.
Gareau et al. (2018) [33] 101 Pre & post-KT 17 U/mL Pre-KT AT1R Ab were more likely to develop de novo DSA and associated with early T cell mediated rejection.
Min et al. (2018) [14] 359 Pre-KT 10 U/mL Microvascular inflammation was associated with pre-KT AT1R Ab.
Pre-KT AT1R Ab was an independent risk factor for allograft failure.
Pearl et al. (2018) [13] 65 (Pediatric) Pre & post-KT 17 U/mL Demonstrated association between AT1R Ab and allograft loss, decline in renal function and vascular inflammation.
Philogene et al. (2018) [32] 170 Pre-KT 17 U/mL Patients with pre-KT AT1R Ab had increased post-KT serum creatinine levels and developed abnormal biopsy findings.

AT1R, angiotensin II type 1 receptor; KT, kidney transplantation; NA, not available; Ab, antibody; DSA: donor-specific human leukocyte antigen antibody; MICA, major histocompatibility complex class I chain-related gene A; AMR, antibody-mediated rejection; HLA, human leukocyte antigen.

J Korean Soc Transplant 2019;33:6~12
© Korean Journal of Transplantation