Table. 2.

Risk factors associated with graft failure

Risk factor Univariate analysis Multivariate analysis


HR (95% CI) P-value HR (95% CI) P-value
Recipient
Age 0.99 (0.98–1.00) 0.054 - -
Sex 1.09 (0.82–1.44) 0.557 - -
BMI 1.05 (1.01–1.09) 0.021 1.04 (1.00–1.08) 0.074
DM 1.43 (1.00–2.04) 0.050 1.26 (0.87–1.82) 0.227
HTN 0.74 (0.54–1.03) 0.078 - -
Donor
Age 1.03 (1.02–1.04) <0.001 1.03 (1.02–1.04) <0.001
Sex 0.79 (0.60–1.04) 0.095 - -
BMI 1.01 (0.97–1.06) 0.518 - -
DM 1.01 (0.14–7.23) 0.991 - -
HTN 0.66 (0.21–2.06) 0.471 - -
sCr 0.66 (0.28–1.56) 0.341 - -
History of KT 0.68 (0.28–1.66) 0.402 0.83 (0.34–2.02) 0.677
ABO incompatible 2.16 (1.18–3.96) 0.013 1.64 (0.88–3.05) 0.118
Inductive agent
r-ATG vs. no agent 1.41 (0.91–2.19) 0.128 - -
Basiliximab vs. no agent 1.16 (0.81–1.65) 0.429 - -
r-ATG vs. basiliximab 1.22 (0.78–1.91) 0.386 - -
No. of HLA I mismatches 1.28 (0.96–1.71) 0.100 - -
No. of HLA II mismatches 1.82 (1.29–2.56) <0.001 1.63 (1.15–2.32) 0.006
DSA(+) 1.68 (0.88–3.20) 0.117 - -
Total operation time 1.00 (0.99–1.00) 0.961 - -
Cold ischemic time 1.00 (1.00–1.00) 0.090 - -
Anastomosis time 0.99 (0.99–1.01) 0.573 -

HR, hazard ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; sCr, serum creatinine; KT, kidney transplantation; r-ATG, rabbit anti-thymocyte antigen; HLA, human leukocyte antigen; DSA, donor-specific antibody.

Korean J Transplant 2022;36:173~179 https://doi.org/10.4285/kjt.22.0018
© Korean Journal of Transplantation