Table. 3.

Risk factor analysis of acute rejection

Risk factor Univariable Multivariablea)


HR (95% CI) P-value HR (95% CI) P-value
Recipient
Age 0.988 (0.978–0.997) 0.012 0.980 (0.969–0.990) <0.001
Male 1.468 (1.179–1.829) 0.001 1.486 (1.176–1.878) 0.001
BMI 1.026 (0.995–1.058) 0.103 - -
DM 0.099 (0.740–1.323) 0.941 -
HTN 0.903 (0.692–1.177) 0.451
Underlying kidney disease 2b) 0.071 - 0.412
DM nephropathy ref -
GN (IgA, FSGS, others) 0.980 (0.702–1.370) 0.908 0.924 (0.645–1.325) 0.669
ADPCK 1.461 (0.878–2.429) 0.144 1.275 (0.755–2.153) 0.364
Hypertensive 0.883 (0.596–1.307) 0.534 0.945 (0.627–1.423) 0.786
Other and UK 0.778 (0.560–1.081) 0.135 0.811 (0.571–1.151) 0.241
Dialysis duration 0.976 (0.924–1.031) 0.382 - -
Pre-emptive KTc) 1.015 (0.798–1.29) 0.905 - -
HLA mismatch 1.180 (1.103–1.263) <0.001 1.145 (1.065–1.231) <0.001
DSA-positive 1.701 (1.013–2.856) 0.045 2.013 (1.012–4.004) 0.046
Induction agent 0.009 0.015
No agent - ref - -
Basiliximab 1.332 (1.061–1.673) 0.014 1.257 (0.990–1.597) 0.061
r-ATG 1.958 (1.277–3.004) 0.002 1.965 (1.269–3.043) 0.003
r-ATG+rituximab 1.153 (0.676–1.966) 0.602 0.984 (0.489–1.982) 0.964
Donor
Male 0.953 (0.770–1.177) 0.653
BMI 1.018 (0.986–1.052) 0.270
DM 0.925 (0.231–3.704) 0.912
HTN 1.624 (0.913–2.889) 0.099 1.326 (0.739–2.379) 0.344
Cr 0.780 (0.406–1.498) 0.455
Older donor groupd) 1.999 (1.285–3.109) 0.002 1.704 (1.042–2.784) 0.034

HR, hazard ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; GN, glomerulonephritis; IgA, immunoglobulin A; FSGS, focal segmental glomerulosclerosis; ADPCK, autosomal dominant polycystic kidney disease; UK, unknown; KT, kidney transplantation; HLA, human leukocyte antigen; DSA, donor specific anti-HLA antibodies; r-ATG, rabbit anti-thymocyte globulin; Cr, creatinine.

a)Variables with a P-value of less than 0.1 in the univariable analysis were included in the multivariable analysis; b)Underlying kidney disease 2 and recipient DM have a high relationship; if both variables had P<0.1, only recipient DM was included in multivariable analysis; c)Pre-emptive KT was defined as kidney transplantation after dialysis duration of less than 30 days; d)Reference is younger donor group, which is the group of KT donors younger than 60 years old.

Korean J Transplant 2021;35:238~246 https://doi.org/10.4285/kjt.21.0020
© Korean Journal of Transplantation