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Review Article

J Korean Soc Transplant 2016; 30(2): 69-76

Published online June 30, 2016

https://doi.org/10.4285/jkstn.2016.30.2.69

© The Korean Society for Transplantation

Current Status of Solid Organ Xenotransplantation

Ik Jin Yun, M.D.

Department of Surgery, Konkuk University School of Medicine, Seoul, Korea

Correspondence to: Ik Jin Yun
Department of Surgery, Konkuk University Hospital, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
Tel: 82-2-2030-7583, Fax: 82-2-2030-7749
E-mail: ijyun@kuh.ac.kr

Received: June 20, 2016; Accepted: June 20, 2016

Abstract

Solid organ xenotransplantation using transgenic pig organs is proposed as an alternative method for allo-transplantation. To accomplish this, immunologic and non-immunologic barriers for xenotransplantation should be overcome, and experiments on pigs to non-human primates (NHP) are now ongoing for clinical application. Before the clinical experiment, public consensus about ethical decisions must be considered. The results of NHP experiments on solid organ xenotransplantation are improving, and it is expected that xeno-solid organs can be used as new organs for human patients in the future.

Keywords: Xenotransplantation, Solid organ transplantation, Transgenic pig