Korean J Transplant 2019; 33(4): 135-145
Published online December 31, 2019
© The Korean Society for Transplantation
Jinsoo Rhu1, Kyo Won Lee1, Young Jae Chung1, Jae Berm Park1, Ju Young Choi1, Sung Joo Kim1, Jin Sang Jung2, Sehyun Kim3
1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;
2Astellas Pharma Korea Inc., Seoul, Korea;
3Graduate School, Dankook University, Yongin, Korea
Correspondence to: Sehyun Kim
Graduate School, Dankook University, 152 Jukjeon-ro, Suji-gu, Yongin 16890, Korea
Tel: +82-31-8005-3952, Fax: +82-2-3448-0511 E-mail: firstname.lastname@example.org
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: This study aimed to develop and validate the Kidney Transplantation and Quality of Life (KTQoL) questionnaire to evaluate the quality of life (QoL) in Korean kidney transplantation (KT) patients. During the validation, the KTQoL was used to compare the QoL of KT patients before and after conversion from twice-daily to a once-daily regimen of tacrolimus.
Methods: Construct and content validity of the 24-item KTQoL was evaluated using factor analysis and a panel of experts, respectively. The questionnaire was validated in 50 KT patients, conducted before and after conversion from twice-daily to once-daily tacrolimus. Internal consistency was evaluated based on Cronbach’s alpha coefficient.
Results: The KTQoL showed high internal consistency (Cronbach’s alpha 0.71 to 0.88). Besides the Concerns category, both the general and specific QoL of KT patients were relatively good (≥70% of positive responses) and did not change markedly after conversion to the once-daily regimen (42.9±8.8 vs. 43.6±8.6, P=0.740). After conversion, men scored better than women in total KTQoL, Specific QoL, and Symptoms, while employed patients had better Daily Life scores and showed greater improvement in Daily Life scores compared with unemployed patients.
Conclusions: The KTQoL seems to be a reliable instrument to evaluate general and specific QoL in Korean KT patients. Most patients evaluated their QoL positively. Conversion to once-daily tacrolimus had no significant effect on QoL in the total sample of KT patients. The QoL of men and/or employed persons might improve more after conversion to once-daily tacrolimus.
Keywords: Medication adherence, Kidney transplantation, Quality of life, Validation studies, Surveys, Surveys and questionnaires, Psychometrics
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