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Review Article

Korean J Transplant 2019; 33(4): 74-82

Published online December 31, 2019

https://doi.org/10.4285/jkstn.2019.33.4.74

© The Korean Society for Transplantation

Macrophages in xenotransplantation

Jae Young Kim

Department of Life Science, Gachon University, Seongnam, Korea

Correspondence to: Jae Young Kim
Department of Life Science, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam 13120, Korea
Tel: +82-31-750-4762 E-mail: jykim85@gachon.ac.kr

Received: December 9, 2019; Revised: December 19, 2019; Accepted: December 19, 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed the involvement of macrophages in xenograft and allograft rejections. Macrophages have been shown to play a critical role in inflammation, coagulation, and phagocytosis in xenograft rejection. This review presents a recent understanding of the role of macrophages in xenograft rejection and possible strategies to control macrophage-mediated xenograft rejection.

Keywords: Xenotransplantation, Macrophages, Inflammation, Coagulation