Table. 3.

Risk factors associated with graft failure in kidney transplant recipients with CABMR

Variable Univariate Multivariate


HR 95% CI P-value HR 95% CI P-value
Recipient age 0.999 0.935–1.067 0.971
Recipient male sex 0.723 0.169–3.096 0.662
Donor age 1.009 0.950–1.070 0.777
Donor male sex 1.281 0.339–4.849 0.715
Deceased donor kidney transplantation 6.542 1.246–34.359 0.026 57.013 1.698–1,914.123 0.024
Thymoglobulin induction 1.656 0.175–15.707 0.660
Previous acute rejection 0.427 0.053–3.450 0.425
HLA mismatches 0.640 0.385–1.065 0.086
PRA >50% at diagnosis of CABMR 0.791 0.186–3.359 0.751
DSA positivity at diagnosis of CABMR 0.511 0.136–1.925 0.321 8.893 0.492–160.725 0.139
eGFR at 12 months after diagnosis of CABMR 0.893 0.800–0.995 0.043 0.850 0.738–0.980 0.025
Proteinuria >1.5 g/day 13.912 1.732–111.711 0.013 3.355 0.132–85.048 0.463
Rituximab and IVIG 1.730 0.430–6.969 0.441 0.259 0.022–2.984 0.279

CABMR, chronic antibody-mediated rejection; HR, hazard ratio; CI, confidence interval; HLA, human leukocyte antigen; PRA, panel reactive antibody; DSA, donor-specific antibody; eGFR, estimated glomerular filtration rate; IVIG, intravenous immunoglobulin.

Korean J Transplant 2021;35:33~40 https://doi.org/10.4285/kjt.20.0052
© Korean Journal of Transplantation